PURPOSE
To lay down the procedure for the solubility of the materials
APPARATUS
Analytical balance
Stoppered test tubes - 10 ml, 20 ml & 50 ml
Conical flasks – 100 ml & 250 ml
Graduate pipettes / Bulb pipettes
REAGENTS
Freshly distilled water
Organic solvents such as methanol, ethanol, methylene chloride etc. - AR grade
PROCEDURE
- Transfer an accurately weighed sample into a glass-stoppered test tube and add a specified quantity of solvent as per the table given below.
- Shake vigorously for one minute, and keep aside for 15 minutes.
- In case, if the sample is not completely dissolved, repeat step 2.
- The term miscible is used for liquid samples and describes a sample that is miscible in all proportions with the stated solvent.
Descriptive term | Approximate volume of solvent in milliliters per gram of solute |
Very soluble Freely soluble Soluble Sparingly soluble Slightly soluble Very slightly soluble Practically insoluble | Less than 1 From 1 to 10 From 10 to 30 From 30 to 100 From 100 to 1000 From 1000 to 10000 More than 10000 |
REFERENCES
USP, BP and Pharmeuropa Technical Guide issued in December 1999.
Notes
- To check the solubility for very soluble, free soluble, soluble, and sparingly soluble use 100mg to 1000mg of sample.
- To check the solubility for slightly, very slightly, and practically insoluble use 10 mg to 100 mg of sample.
Tags
GTP
