Wet Screening
Causes: Remedies
- Doughy or sticky wet mass:
- Avoid oscillating granulators.
- Use an extrusion-type granulator or Fitz Mill without screens.
- Reduce granulation time
- Add 5% to 20% Avicel PH-101 (gives less sticky or doughy mass, easier to screen)
- Too much water in mass: Reduce water content; add water gradually and mix well after each addition.
- Mass sensitive to water content: Incorporate 5% to 20% Avicel PH-101 (allows a wider range of solvent volume).
- Gummy binder: Change the binder
- Component or active ingredient: Use diluted or anhydrous ethyl or isopropyl alcohol (if latter, determine acceptable residual solvent level by GC or another appropriate method); change binder.
ALSO READ: Problems and Remedies for Dry Blending
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