PURPOSE
To lay down the procedure for testing of miscellaneous solvents
INSTRUMENTATION
Not applicable
REAGENTS
Not applicable
PROCEDURE
Description
- Visually observed the solvents and note down the observation in the record.
Solubility
- Refer to pharmacopeia for respective solvents and it shall be tested.
Identification
- The retention time of the major peak in the chromatogram of the sample corresponds to that of the standard obtained as directed in the purity test.
- Place the bottle in the drying chamber (oven or desiccators) as directed in the individual test procedure, remove the stopper and leave it also in the chamber.
- Dry the sample to constant weight or for a specified time and at the temperature indicated in the individual test procedure.
- Constant weight: Two consecutive weights should not differ not more than 0.50 mg.
- After drying is completed, open the drying chamber, close the bottle promptly and allow it to cool to room temperature in desiccators before weighing.
- Weigh the bottle and contents.
Calculation
Empty LOD bottle weight: W1
LOD bottle + sample weight: W2
After drying LOD bottle + sample weight: W3
REFERENCES
British Pharmacopeia
Tags
GTP
