Objective
The purpose of this STP is to ensure the compliance of quality of Non-Absorbent Cotton Roll
Scope
To establish the standard testing procedure of Non-Absorbent Cotton Rolls in Pharmaceuticals.
Procedure
Description
- Cotton Wool - Non-Absorbent Cotton Roll.
Packaging
- Package in rolls of not more than 500gm of the continuous lap, with a light-weight paper running under the entire lap, the paper being of such width that it may be folded over the edges of the lap, the two together being tightly and evenly rolled, enclosed and sealed in a well-closed container.
Weight
- Weight the cotton roll accurately and note the weight. The weight should be within the specified limit.
ALSO READ: Method of Analysis for Total Coloring Matter
Identification
- Treat with iodinated zinc chloride solution, the fibers become violet.
- To 0.1gm add 10ml of zinc chloride solution, heat to 40, and allowed to stand for 2 and half hours, shaking occasionally: the fibers do not dissolve.
Acidity or Alkalinity
- To 15gm add 150ml of water, macerate for 2 hours in a closed vessel, decant the liquid, carefully squeeze out the residue liquid with a glass rod, and mix. To 25ml of this solution add 0.1ml of dilute phenolphthalein solution; to another 25ml add 0.05ml of methyl orange solution. Neither solution shows a pink color.
Loss on Drying
Procedure:
- Keep the L.O.D. bottle and stopper in the oven and maintain temp. 105°C for 30 minutes. Allow to cool the bottle in a desiccator to room temperature and weigh it accurately with a stopper.
- Take the sample around 5 gm in the bottle and weigh it accurately with a stopper.
- Keep the same in the oven at 105°C for constant weight without a stopper. Take out the bottle put the stopper and allow to cool the bottle in a desiccator to room temperature. Weigh the bottle again.
Calculation:
A = Weight of the bottle and the sample with stopper before drying.
B = Weight of empty bottle with stopper.
C = Weight of the bottle and the sample with stopper after drying.
Tags
Test Method
